Monoamine Oxidase Inhibitor

Pirlindole hydrochloride is an orally active, selective and reversible MAO-A inhibitor with an IC₅₀ value of 250 nM. Pirlindole hydrochloride inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole hydrochloride inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole hydrochloride shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole hydrochloride can be used in research related to depression and enterovirus infections.

OG-L002 hydrochloride is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 hydrochloride is a potent monoamine oxidases (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 hydrochloride potently inhibits the expression of HSV IE genes.

GSK-LSD1 (dihydrochloride) (Standard) is the analytical standard of GSK-LSD1 (dihydrochloride) (HY-100546A). This product is intended for research and analytical applications. GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.

MD 780236 free base is a substrate and selective inhibitor of monoamine oxidase B (MAO-B), competitive with phenylethylamine and 5-hydroxytryptamine (5-HT).

Safinamide-d₅ (FCE 26743-d₅) is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.098 μM) over MAO-A (IC₅₀=580 μM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8?μM) than at resting (IC₅₀=262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.

Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC₅₀3.6 μM). Methylpiperic acid is less effective against MAO-B (IC 501.6 μM) than MAO-A (IC₅₀27.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to research mental disorders .

Caroxazone is a reversible inhibitor for monoamine oxidase (MAO). Caroxazone exhibits activity as an antidepressant agent.

4-Chlorochalcone (Compound 3) is a monoamine oxidase inhibitor (hMAO-B: IC₅₀ = 0.082 μM, hMAO-A: IC₅₀ = 9.95 μM). 4-Chlorochalcone also exhibits inhibitory activity against cholinesterase (AChE: IC₅₀ = 2.79 μM). 4-Chlorochalcone is a chalcone derivative.

Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC₅₀ values ​​of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible MAO inhibitor that can be used in the research of neurodegenerative diseases and affective disorders.

2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO), that inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC₅₀ of 120 μM and 190 μM.

RS 8359 (Standard) is the analytical standard of RS 8359. This product is intended for research and analytical applications. RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity.

Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor.

MAO-B-IN-57 is a selective MAO-B inhibitor with an IC₅₀ of 41.38 nM against human MAO-B. MAO-B-IN-57 shows no significant in vitro cytotoxicity and can significantly increase the survival rate of PC12 cells damaged by 6-OHDA. MAO-B-IN-57 can be used in studies related to Parkinson's disease.

MD 770222, a major plasma O-demethyl metabolite of Cimoxatone (HY-15386), is an orally active, selective and reversible MAO A inhibitor. MD 770222 shows less potent than Cimoxatone.

6,7-Dimethylisatin (compound 1l), an Isatin (HY-Y0265) analogue, is a potent MAO inhibitor with IC₅₀s of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively. 6,7-Dimethylisatin has the potential for depression, Alzheimer's disease and Parkinson's disease research.

MAO-B-IN-1 is an inhibitor of monoamine oxidase B, used for the research of neurological diseases.